The preparation and purification of tritiated carcinogenic hydrocarbons.

نویسندگان

  • B C GIOVANELLA
  • C W ABELL
  • C HEIDELBERGER
چکیده

Methods have been described for the preparation of tritiated carcinogenic polycyclic aromatic hydrocarbons of high specific activity by the Wilzbach method. A large num ber of highly radioactive impurities were produced during the exposure to tritium gas, and extensive purification was required. This was achieved by column chromatography followed by various paper Chromatographie systems with some novel modifications. The following compounds were labeled by this method: 10-methyl-l,2-benzanthracene, 3-methyl-l,2-benzanthracene, 4-methyl-l,2-benzanthracene, 3-fluoro-10-methyl-l,2benzanthracene, 4-fluoro-10-methyl-l,2-benzanthracene, 1,2,5,6-dibenzanthracene, 1,2,3,4-dibenzanthracene, 9,10-dimethyl-l,2,5,6-dibenzanthracene, 3,4-benzpyrene, 3methylcholanthrene, 9,10-dimethyl-l,2-benzanthracene, anthanthrene, and 2-phenylphenanthrene-3,2'-dialdehyde.

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عنوان ژورنال:
  • Cancer research

دوره 22  شماره 

صفحات  -

تاریخ انتشار 1962